Burt formulates her critique at a general level of abstraction that highlights the methodological deficiencies of sociogenomics without also calling attention to precisely the same deficiencies in the social science model she seeks to defend against its encroachments. What might have been a methodological bulwark against the excesses of sociogenomics is instead a one-sided critique that merely renews its charter.

The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

Em seu livro Mente e Mundo John McDowell pretende superar a oscilação entre duas abordagens que pretendem mediar à relação entre as mentes e o mundo, de um lado temos o mito do dado dizendo que os pensamentos precisam de uma coerção a partir do mundo exterior, e do outro lado temos o coerentismo que apresenta a ideia de que apenas uma crença pode justificar outra crença. Para defender sua abordagem e naturalizar as capacidades conceituais, situando a espontaneidade na (...) natureza sem reduzi-la no interior do reino da lei. A natureza humana seria então uma segunda natureza que não é só formada a partir das capacidades adquiridas no nascimento, mas que são formadas também a partir da Bildung. Ao lançar mão dessas noções, McDowell traz a discussão das ideias de Han-Georg Gadamer sobre a experiência de abertura para o mundo através da linguagem. Deste modo, a intenção do presente artigo é de discutir sobre as implicações das noções de Bildung e segunda natureza na obra de McDowell buscando um maior esclarecimento a partir da influência e das interpretações de Gadamer. (shrink)

Rule-following is a normative doing and therefore needs to be reconsidered in a metaethical framework. Rule-following will be discussed in the light of cognitivism and non-cognitivism. It will be shown that neither cognitivism nor non-cognitivism are sufficiently good accounts for conceptualizing rule-following, because they are held captive by a quasi-mechanistical picture of rule-following. This idea stems from Stanley Cavell´s and John McDowell´s approach to rule-following. McDowell appeals to the idea that we participate in “shared forms of life” and therefore (...) are able to follow rules correctly. I believe that his quietist view can be amplified by conceptualizing different modes of following a rule. We can also follow a rule e.g. ironically and still grasp the conceptual content of the rule adequately. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:"EVERY MARITAL ACT OUGHT TO BE OPEN TO NEW LIFE'': TOWARD A CLEARER UNDERSTANDING I. INTRODUCTION NE FREQUENTLY encounters misinterpretations of the statement " Every marital act ought to be open to new life " and similar statements in recent Catholic teaching concerning contraception.1 There are two common misinterpretations. One is: No couple may engage in marital intercourse without the intention to procreate. The other is: No couple may (...) engage in marital intercourse at times when they think procreation is impossible. As interpretations of the Church's teaching, these must be mistaken. For the Church teaches that contraception is always wrong and that natural family planning (NFP) is not always wrong. But NFP facilitates intercourse without the intention to procreate at times when procreation is thought to be impossible. Moreover, the Church has never taught that marital intercourse is good only if the couple desires to procreate; indeed, couples known to be sterile have never been forbidden to marry. We think that the only plausible interpretation of "Every marital act ought to be open to new life" is: It is wrong for those who engage in marital intercourse to attempt to impede the transmission of life which they think their act otherwise might bring about. For if they do try to impede that to which their act of itself might lead, they choose to close it to new life. 1 The proposition is formulated somewhat differently by Paul VI, Humanae vitae, 11, AAS 60 (1968), 488 (with references to Gasti connubii and to Pius XII's.Allocution to the Society of Italian Catholic Midwives); and by John Paul II, Familiaris consortia, 29, AAS 74 (1982), 115, following proposition 22 of the 1980 session of the Synod of Bishops. Moreover, the different formulations also are translated diversely. We do not think these differences matter for our present purpose. 365 366 GRISEZ, BOYLE, FINNIS AND MAY Un.derstood in this way, "Every marital act ought to be open to new life" expresses the same proposition as " Contraception is always wrong." Nevertheless, the affirmative formulation helps to clarify what contraception is, for it indicates the precise object of the contraceptive act. "Contraception" signifies only the prevention of conception, but the contraceptive act seeks to impede the beginning of the Zife of a possible person. The distinction is only conceptual, but we think it important, for the explicit reference to new life calls attention to the fact that contraception is a contralife act. The characterization of contraception as a oontralife act is one major element of the unbroken Christian tradition condemning contraception as always wrong. For example, a canon, Si aliquis, concerning contraception was included in the Church's universal law from the thirteenth century until 1917: " I£ anyone for the sake of fulfilling sexual desire or with premediated hatred does something to a man or to a woman, or gives something to drink, so that he cannot generate, or she cannot conceive, or offspring be born, let it be held as homicide." 2 This canon does not say that contraception is homicide ; the tradition made no such mistake. The canon rather says that contraception sihould be regarded as homicide is regarded. To regard contraception as homicide is regarded is not only to make it clear that.contraception is wrong, but also to point to its being contralife as the reason why it is wrong. When contraception is regarded as contralife, it is seen as evil outside marriage as well as within. Historically, contraception probably was more common among the unmarried than the married, and much of the tradition condemned contraception without distinguishing between its uses in and outside mar2 Deoret. Greg. IX, lib. V, tit. 12, cap. v; Oorpus iuris oanonioi, ed. A. L. Richter and A. Friedberg (Leipzig: Tauchnitz, 1881), 2, 794: "Si aliquis causa explendae libidinis vel odii meditatione homini aut mulieri aliquid fecerit, vel ad potandum dederit, ut non possit generare, aut concipere, vel nasci soboles, ut homicida. tenea.tur." Some transla.te "ca.usa explendae libidinis," which is broad enough to cover all motivation by sexual impulse, "to satisfy lust," which unnecessarily limits the motive to habitual vice. " OPEN TO NEW LIFE " 367 riage. But. Casti oonnubii dealt with contraception... (shrink)

_A new theory of how and why we cooperate, drawing from economics, political theory, and philosophy to challenge the conventional wisdom of game theory_ Game theory explains competitive behavior by working from the premise that people are self-interested. People don’t just compete, however; they also cooperate. John Roemer argues that attempts by orthodox game theorists to account for cooperation leave much to be desired. Unlike competing players, cooperating players take those actions that they would like others to take—which Roemer (...) calls “Kantian optimization.” Through rigorous reasoning and modeling, Roemer demonstrates a simpler theory of cooperative behavior than the standard model provides. (shrink)

How far does a researcher’s responsibility extend when an incidental finding is identified? Balancing pertinent ethical principles such as beneficence, respect for persons, and duty to rescue is not always straightforward, particularly in neuroimaging research where empirical data that might help guide decision making are lacking. We conducted a systematic survey of perceptions and preferences of 396 investigators, research participants, and Institutional Review Board members at our institution. Using the partial entrustment model as described by Richardson, we argue that our (...) data supports universal reading by a neuroradiologist of all research MRI scans for incidental findings and providing full disclosure to all participants. (shrink)

Examines Arthur Schopenhauer's (1788-1860) conception of human agency and responsibility, his unique ethics of the morally virtuous character, and his assessment of life as fundamentally suffering. This title focuses on his contention that the human will and the human body cannot have a cause and effect relationship with each other.

In the first comprehensive biography of Ferdinand de Saussure, John E. Joseph restores the full character and history of a man who is considered the founder of modern linguistics and whose ideas have influenced literary theory, philosophy, cultural studies, and virtually every other branch of humanities and the social sciences.

As a work of a scholarship it seems to me to compare favourably with the best books on the subject, including those by Marcus Singer and Onora Nell.' Prof.

Introduction Marxism is a set of ideas from which sprang particular approaches to economics, sociology, anthropology, political theory, literature, art, ...

We prove the following extension of a result of Keisler and Morley. Suppose U is a countable model of ZFC and c is an uncountable regular cardinal in U. Then there exists an elementary extension of U which fixes all ordinals below c, enlarges c, and either (i) contains or (ii) does not contain a least new ordinal. Related results are discussed.

In this remarkable survey of "the communicative repertory of humans," John Gedo demonstrates the central importance to theory and therapeutics of the communication of information. He begins by surveying those modes of communication encountered in psychoanalysis that go beyond the lexical meaning of verbal dialogue, including "the music of speech," various protolinguistic phenomena, and the language of the body. Then, turning to the analytic dialogue, Gedo explores the implications of these alternative modes of communication for psychoanalytic technique. Individual chapters (...) focus, in turn, on the creation of a "shared language" between analyst and analysand, the consequences of the analytic setting, the form in which the analyst casts particular interventions, the curative limits of empathy, the analyst's affectivity and its communication to the patient, and the semiotic significance of countertransference and projective identification. Gedo does not proffer semiotics as a substitute for metapsychology. He is explicit that communicative skill is always dependdent on somatic events within the central nervous system. Indeed, it is because Gedo's hierarchical approach to communication builds on our current understanding of a hierarchically organized central nervous system that his clincal observations become insights into basic psychobiological functioning. Grounded in Gedo's four decades of clinical experience, _The Languages of Psychoanalysis_ points to a new venue of clinical research and conceptualization, one in which attentiveness to issues of communication will not only foster linkages with contemporary neuroscience, but also clarify and enlarge the therapeutic possibilities of psychoanalytic treatment. (shrink)

This work is an exploration of divine command theory, which is the theory that what makes something morally obligatory is that God commands it.

This review of Martin Jay’s recent published collection of essays examines his ongoing rethinking, supplementation, and revision of central themes—the negative and positive dialectics of historical totalization, the varieties and uses of conceptions of experience, the nature of visual cultures and scopic regimes, and the ambiguities of truth-construction in the public realm—that have been the focus of his major works since the 1970s. It argues that his more recent work indicates a gradual shift toward an affirmation of the kinds of (...) paratactic and deconstructive thinking of Adorno and Derrida as models for producing appropriate forms of historical consciousness and historical critique in the present, and it raises the question of how the issues of historical truth-telling, consensual collective identity, ethical action, and the cultural role of the critical intellectual are reformulated in this process. (shrink)

The principle of indifference has fallen from grace in contemporary philosophy, yet some papers have recently sought to vindicate its plausibility. This paper follows suit. In it, I articulate a version of the principle and provide what appears to be a novel argument in favour of it. The argument relies on a thought experiment where, intuitively, an agent’s confidence in any particular outcome being true should decrease with the addition of outcomes to the relevant space of possible outcomes. Put simply: (...) the greater the number of outcomes, the weaker your confidence should be in any one of those outcomes. The argument holds that this intuition favours the principle of indifference. I point out that, in contrast, the intuition is also incompatible with a major alternative to the principle which prescribes imprecise credences: the so-called wide interval view. Consequently, the argument may also be seen as an argument against the wide interval view. (shrink)

This book presents a detailed fieldwork-based study of the ancient Indian religion of Jainism. Drawing on field research in northern Gujarat and on the study of both ancient Sanskrit and Prakrit and modern vernacular Jain religious literature, John Cort provides a rounded portrait of the religion as it is practiced today.

This book, first published in 1990, takes a critical look at the major assumptions which support critical thinking programs and discovers many unresolved questions which threaten their viability. John McPeck argues that some of these assumptions are incoherent or run counter to common sense, while others are unsupported by the available empirical evidence. This title will be of interest to students of the philosophy of education.

Establishes the importance of Husserl's phenomenology for Levinas's ethics.

In 1981, the Atlantic Council's Energy Policy Committee, in collaboration with the Japanese Committee for Energy Policy Promotion and the Japanese Institute of Energy Economics, published a joint policy paper entitled 'U.S.-Japan Energy Relationships in the 1980s.'.

Continuous recordings of brain electrical activity were obtained from a group of 176 patients throughout surgical procedures using general anesthesia. Artifact-free data from the 19 electrodes of the International 10/20 System were subjected to quantitative analysis of the electroencephalogram (QEEG). Induction was variously accomplished with etomidate, propofol or thiopental. Anesthesia was maintained throughout the procedures by isoflurane, desflurane or sevoflurane (N = 68), total intravenous anesthesia using propofol (N = 49), or nitrous oxide plus narcotics (N = 59). A set (...) of QEEG measures were found which reversibly displayed high heterogeneity of variance between four states as follows: (1) during induction; (2) just after loss of consciousness (LOC); (3) just before return of consciousness (ROC); (4) just after ROC. Homogeneity of variance across all agents within states was found. Topographic statistical probability images were compared between states. At LOC, power increased in all frequency bands in the power spectrum with the exception of a decrease in gamma activity, and there was a marked anteriorization of power. Additionally, a significant change occurred in hemispheric relationships, with prefrontal and frontal regions of each hemisphere becoming more closely coupled, and anterior and posterior regions on each hemisphere, as well as homologous regions between the two hemispheres, uncoupling. All of these changes reversed upon ROC. Variable resolution electromagnetic tomography (VARETA) was performed to localize salient features of power anteriorization in three dimensions. A common set of neuroanatomical regions appeared to be the locus of the most probable generators of the observed EEG changes. (shrink)

Short-term or working memory provides temporary storage of information in the brain after an experience and is associated with conscious awareness. Neurons sensitive to the multiple stimulus attributes comprising an experience are distributed within many brain regions. Such distributed cell assemblies, activated by an event, are the most plausible system to represent the WM of that event. Studies with a variety of imaging technologies have implicated widespread brain regions in the mediation of WM for different categories of information. Each kind (...) of WM may thus be expected to involve many brain regions rather than a local, uniquely dedicated set of cells. Neurons in a distributed “cell assembly” may be self-selected by their temporally coherent activations. The process by which this fragmented representation of the recent past is reassembled to accomplish essentially automatic and reliable recognition of a recurrent event constitutes an important problem. One plausible mechanism to achieve the identification of past with previous events would require that the representational system mediating WM must coexist in spatial extent and somehow overlap in temporal activation with cell ensembles registering input from subsequent events. The detection of such a postulated mechanism required an experimental approach which would focus upon spatial patterns of coherent activation while information about different events was stored in WM and retrieved, rather than focusing upon the temporal sequences of activation in localized regions of interest. For this purpose, the familiar delayed matching from sample task was modified. A series of information-free flashes, or “noncontingent probes,” was presented before an initial series of visual information items, the Priming Sample, which were to be held in WM during a Delay Period. A second series of visual information items were then presented, the Matching Sample. The task required detection of any item in the second series which had beenabsentfrom the initial series. Thirty such trials with a particular category of visual information constituted a single task. Several DMS tasks with this standardized design, but with different categories of visual information, were presented within each test session. The information categories included letters of the alphabet, single digit numbers, or faces from a school yearbook. Event-related potentials , were computed from 21 standardized electrode placements, separately for information-free probes and for information items in each interval of the trials within a task. Because each electrode is particularly sensitive to coherent activation of neurons in the immediately underlying brain regions, topographic maps were constructed and interpolated across the surface of the scalp. The momentary fluctuations of the resulting voltage “landscapes” throughout the task were then subjected to quantitative analysis. Distinctive landscapes sometimes persisted for prolonged periods, implying sustained engagement of very large populations of neurons. “Difference landscapes” were constructed by subtraction of topographic maps evoked by noncontingent probes during the Delay Period from maps of probe ERPs before the presentation of the initial information in the Priming Sample. Such probe difference landscapes displayed recurrent high similarity to momentary landscapes elicited during subsequent presentation of the information items in the Matching Sample. It seemed as if the distributed cell assembly continuously engaged by mediation of WM of the diverse attributes of the initial stimuli was being dynamically compared to the ensembles engaged by registration of the subsequent stimuli. Spatial Principal Component Analysis was applied to the sequences of momentary voltage landscapes observed throughout trials of each task. This method sought a small number of spatial patterns with which these large sets of inhomogeneous spatial distributions of voltage could be reconstructed. This is the spatial analog of the reconstruction of local ERPs by temporal principal components, as often described previously. Five Spatial Principal Components were found which accounted for about 90% of the total variance of voltage across the surface of the scalp throughout every task. Theloadings,or distinguishing topographic features, of these SPCs, were highly similar during every cognitive task for every subject. However,factor scores,or relative average contribution to the overall voltage distributions, of the different SPCs varied substantially among subjects between the tasks and momentarily within successive intervals of each task. These five SPCs may reflect coherent activation of huge distributed ensembles of neurons which comprise independent but interacting functional brain subsystems. These subsystems may correspond to basic resources available to individuals for allocation to mediate conscious evaluation of information during cognitive activity, providing a filter to bind together fractionated representations of the past to evaluate the present. (shrink)

The authors present a materialist analysis of the effects of neoliberalism in education. Specifically, they contend that neoliberalism is a form of cultural invasion that begets necrophilia. Neoliberalism is necrophilous in promoting a cultural desire to fix fluid systems and processes. Such desire manufactures both individuals known and culturally felt experiences of alienation which are, it is argued, symptomatic of an imperialist nostalgia that permeates educational policy and practice. The authors point to ‘unschooling in schools’ as a mechanism for resisting (...) the necrophilous tendencies of contemporary formations of education. (shrink)